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reducing glomerular mesangial cell proliferation by blocking the mitogen-activated protein kinase (MAPK) signaling pathway

4e), the pyruvyl moiety makes hydrogen bonds with residues His193, Asn313, Ser315, Ser317, Thr347, and a water molecule, as well as a covalent linkage with Cys191, resulting in an ICL1-inhibitor covalent adduct

Front Immunol 13:858069

Curr Opin Obstet Gynecol 25:167172

Future Perspective and Conclusion Emergent evidence suggests that several snake venom active components/toxins target the mitochondrial bioenergetics with selective migrastatic and cytotoxic effects on cancer cells