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For instance, elevated CHAC1 mRNA levels are associated with increased recurrence risk in these cancers, underscoring its clinical relevance ( Pan-cancer analyses reveal that CHAC1 expression is highly variable, being upregulated in many cancers (e.g., breast, ovarian, lung, bladder carcinomas) and downregulated in others (e.g., certain head/neck, kidney, and brain cancers) (Li, D

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or (6) used drugs that impair sleep

11 June 2025

It has also been shown to modulate pivotal inflammatory pathways, such as NF-B and MAPK 24,25 , although direct evidence within skin aging models remains limited