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4a-e, Supplementary Data 1): (i) 3xTG, displaying both amyloid plaque and tau tangle pathologies 27 , and (ii) BiGenic (BiG) mice, generated by crossing 5xFAD with N40K transgenic mice recapitulating both amyloid pathology and the newly discovered U1 snRNP splicing dysfunction in AD 45

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You know one of the world famous bowlers was asked, "How do you throw a strike every time?" And he said, "When I was a kid my dad owned the bowling alley, and we didn't have the gutters at that time, or the machine, so he would set up the pins, I would roll the ball down at six years old, and it would go off to the side, and my dad would move two of the pins so I always hit something, I always got a chance of being successful." Now take that as being a metaphor of our job as parents is to create situations that challenge our children, but also create an opportunity for them to feel successful