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As such, fentanyl may act on peripheral structures, brain regions without a bloodbrain barrier, and brain structures within the blood brain barrier 15,20

Thus, GST-peptide-glutathione or GST-glutathione-peptide complex cannot catalyze the conversion of glutathione (Fig 4B and 4C)

These synthetic compounds are referred to as glycomimetics because they mimic the structure and biology of natural product glucans

Long-term injury (LTI) group: The sciatic nerves of the rats in this group were subjected to crush injury for 60 s [8]

Cysteine is known to stimulate glutathione synthesis[23], and cysteine availability is often the limiting factor for intracellular glutathione synthesis[24]