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Vitamin E, scientifically termed tocopherol, demonstrates the capacity to stimulate estrogen biosynthesis and secretory processes (130)

These effects were mediated by suppressing the Smad2/3 signaling pathway, a crucial regulator in fibrosis [19]

doi: 10.1371/journal.ppat.1007464 380 EhlersBSpiessKLeendertzFPeetersMBoeschCGathererDet al

on alcoholic fatty liver disease through regulating intestinal flora and inhibiting TAK1/p38MAPK/p65NF-B pathway

Additionally, we detected a significant increase in insulin receptor (INSR) protein expression in the HFD-IF-KO mice compared to HFD-AL and HFD-IF groups (Fig