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An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

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Similarly, obese individuals exhibit an altered ratio of Bacteroidetes to Firmicutes , which can be ameliorated by a low-calorie diet (131)

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It works downstream of growth hormone and plays a direct role in muscle hypertrophy