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Approximately 88% of newly diagnosed T2DM individuals reported one or more symptoms of the GI tract, 28 with the most common reported being diarrhoea (62%), heartburn (52%), nausea (47%), abdominal pain (36%), bloating (35%) and retching (21%), 29 with the mechanisms for these side effects a result of the actions of the drug in the GI system

2006;10:R27 Disclaimer: Image used for reference only

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Indeed, superoxide can undergo dismutation to H 2 O 2 , a mild oxidant that can be converted to the highly reactive hydroxyl radical in the presence of transition metals (Fe 2 + , Cu + ) by means of the Fenton reaction