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SIRT1 activity may be required for limiting the toxicity of oxidative stress and preserving memory (262), fostering A degradation (586), increase lifespan in higher level organisms (587), and protecting neuronal and vascular cells against oxidative stress (98, 134, 232, 240, 438, 502, 510, 550, 551, 554, 555, 588)

Recently, Kim et al confirmed the effect of insulin on GSH levels and GCLC expression in rat hepatocytes and found that of the signaling pathways activated by insulin, PI3K/Akt/p70S6K are involved in mediating the effect while ERK, JNK and p38 MAPK are not (Kim et al., 2004)