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Quinone compounds such as doxorubicin and menadione have been used as therapeutic drugs

Consequently, exercise is widely promoted as a cornerstone intervention to delay or attenuate sarcopenia, immunosenescence, and the functional impairments that accompany aging

Well, cancer cells can hijack those same pathways

A.JoladarashiD.JeyabalP.KrishnamurthyS.BhimarajA.et al (2016)

This protease-driven nerve activation is now believed to be a major contributor to the visceral hypersensitivity and widespread "nociplastic" pain seen in conditions like irritable bowel syndrome (IBS), ME/CFS, and fibromyalgia