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FIGURE 2 3.1 Mechanisms of ferroptosis 3.1.1 Iron overload is an important cause of ferroptosis Iron overload is a pivotal component in the occurrence of ferroptosis

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Autophagy is activated at senescence, as shown for normal senescent epidermal keratinocytes 30 , normal senescent fibroblasts 31 , long-term cultured T lymphocytes 32 and some tumor cell lines re-induced into senescence after drug treatments 33,34

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