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A confirmed B12 deficiency is diagnosed through a blood test measuring serum B12 levels, along with tests for MMA and homocysteine, which become elevated in deficiency cases

Oxygen to be transported efficiently by erythrocytes depends on the presence of hemoglobin, a protein capable of binding oxygen through its central iron atom (128)

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This approach is based on the physical adsorption of a binding agent onto a surface through forces such as electrostatic interactions, hydrophobic interactions, or hydrogen bonding [79,80]