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While this construct mimicked the first TCR signal upon CAR binding to its target antigen, they lacked the second signal necessary for efficient T-cell activation

Oncogene 21 : 82408250 Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin

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As far as size, this is also dependent on the patients initial breast size, but to achieve a natural looking breast size on a woman similar to Taylors stature and size, implants ranging from 350cc to 450cc may be appropriate

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