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These regions supported the physiological functions of AR as a ligand-dependent transcription factor, allowing testosterone or 5-dihydrotestosterone (DHT) to bind to AR, stabilize the receptor-DNA complex when dimerized AR binds to DNA at specific androgen-response elements (ARE) [20], and modulate transcriptional activation of androgen-dependent genes [21]

Tang, D

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It forms a breathable firming matrix on the skin's surface, hydrating and supporting the under-eye barrier for a smoother, lifted, and brighter appearance starting from the very first use

Recent studies have showed that oral ingestion of L-carnitine in both animals and humans results in generation of trimethylamine by intestinal microbiota, which is absorbed and then metabolized to trimethylamine-N-oxide (TMAO) by liver flavin monoxygenases (FMOs) (especially FMO3 and FMO1) 35,45