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11), recent X-ray crystallography and cryo-EM data revealed that GSH binds the ATD of GLR3.4 30 , another GLR protein with high sequence similarity to GLR3.3, reinforcing that GSH might bind the ATD domain of GLR3.3 for activation of ion channel

As predicted by Polly Matzinger (62, 223), DAMPs trigger the activation of antigen-presenting cells, act as chemokines that recruit dendritic cells, macrophages, or T cells to the site of injury, or prime immune cells, i.e., they contribute to trained immunity (5860, 62, 224226)

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Dual-luciferase reporter assay The mouse Hnf4a promoter sequences were inserted into the NheI/HindIII site of the luciferase pGL3-Basic vector (Promega, USA)

While the prevalence of sporadic CAA increases with age, instances of early-onset CAA have been reported particularly in the context of prior neurosurgical interventions