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For instance, NKCC2 has been found in insulin-secreting -cells (Zhu et al., 2011) or neurons of the hypothalamus (Konopacka et al., 2015), whereas NCC was detected in endothelial and smooth muscle cells, heart, lung and liver (Wang et al., 2015), adipocytes (Zhang et al., 2022a), and -cells as well (Zhang et al., 2022b)

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It suggested that GD activates Nrf2 signaling pathway to increase HO-1 expression to regulate the expression of related proteins [133]

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