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In addition to the rapid and long-lasting antidepressant response, boosting mitochondrial metabolism of LAC leads to the amelioration of specific cognitive domains [46, 47], and promotes behavioral resilience at the social defeat stress (SDS) paradigm [27]

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Then, acetyl-CoA is used directly for the generation of energy by the tricarboxylic acid cycle, or it can be converted to acetylcarnitine via the action of carnitine acetyltransferase for transport out of the mitochondria to be utilized elsewhere

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