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J Clin Med 9(4):1034 Demers LM (2004) Thyroid disease: pathophysiology and diagnosis

ZDHHC2 deficiency attenuates pathological progression in mice by inhibiting pro-inflammatory cytokine expression in inflamed skin and leukocyte infiltration in psoriatic lesion areas, and ZDHHC2 deficiency reduces migration of pDC to the skin and other organs, which reduces psoriasis risk (151)

Future studies should prioritize: in vivo evaluation in infected wound models to assess healing efficacy and safety, mechanistic investigations into antimicrobial and antibiofilm pathways, extended release studies beyond 24 h to correlate with chronic wound healing timelines, and formulation optimization for scalability and regulatory compliance

Studies have mainly explored the regulatory effects of AS-IV on fibrosis from the perspectives of experimental animal models at the cellular, molecular and genetic levels, with most only focusing on single drug components and large-sample placebo-controlled, randomized and standardized double-blind experimental data regarding TCM treatments awaiting further investigation (10,14)