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3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)

doi: 10.3389/fnins.2025.1602149 Received 28 March 2025 Accepted 21 May 2025 Published 04 June 2025 Volume 19 - 2025 Edited by Xiao-Yuan Mao, Central South University, China Reviewed by Cai Qi, Yale University, United States Fiorella Colasuonno, University of Rome Tor Vergata, Italy Updates Copyright 2025 Valenzuela-Ahumada, Mercado-Gmez, Viveros-Contreras, Guevara-Guzmn and Camacho-Morales