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Overall, evidence suggests that patients with neuropathy may benefit most from combined treatment plans that are guided by their specific symptoms, health conditions, and responses to therapy

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267 While there is a need in clinical research to enroll a more homogeneous patient population, this approach raises concerns about the clinical relevance of such studies for the truly heterogeneous IC/BPS population

Although the first studies in this field began over 100 years ago, the investigation of peptides remains a key focus in modern pharmacology [4]

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