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Tachyphylaxis, the diminishing response to repeated drug exposure, appears less pronounced with Sermorelin than with direct growth hormone administration

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Tominersen, a gapmer ASO developed by Ionis and Roche, demonstrated a 40% reduction in cerebrospinal fluid (CSF) mHTT levels in a phase 1/2a trial, with no severe adverse events (Leavitt 2024)

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