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The body produces them when fatty acids are broken down (from fat) as energy sources

Every heartbeat, breath, or thought relies on mitochondrial output

The secondary lesions of AS include lipid deposition, intimal thickening, thrombosis, inflammatory cell infiltration, subintimal inflammation, vessel wall remodeling, neovascularization, plaque rupture, intraplaque hemorrhage, plaque rupture and local thrombosis, which eventually cause narrowing or blockage of the vascular lesion, resulting in ischemic injury to the affected organs (4)

Chemistry of Materials, 2020, 32(23): 98689881 Chen G, Yang Y, Xu Q, Ling M, Lin H, Ma M, Sun R, Xu Y, Liu X, Li N, et al

Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis