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Description

Phase 3 is confirmatory

HEP and HEP-modulators are potential candidates to reset FeRD and reverse iron-overload syndromes such as anemia and chronic kidney disease (CKD) in COVID-19 and PASC patients 27,496,497

Effects are generally more pronounced in deficient individuals

Preclinical studies show that combining decitabine with histone deacetylase inhibitors (e.g., sodium butyrate) synergistically upregulates NIS mRNA expression (by up to 1600-fold) and significantly increases iodine uptake (9-fold in DRO cells, 8-fold in 2-7 cells) [95], supporting epigenetic combination therapy as a viable strategy to overcome resistance