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Multisystem physiological perspective of human frailty and its modulation by physical activity

Another interesting facet of the maintained adaptive response is that the GSH level of roughly 250-300 M may not be arbitrary

25, 38 As aberrations in the TP53 gene and t(4:14) translocations are seen in 15% of patients 49 and correlated with short progression-free survival and resistance to alkylating agents at relapse, 50 the ability of BSO to sensitize MM cells with this phenotype suggests that BSO+L-PAM may have clinical activity in the most aggressive forms of MM

doi: 10.1016/j.ejpb.2016.07.023

In pupil function regulation, these distinct NO-mechanisms (i.e., opposite effects on the same signaling pathway) produced the same physiological response [12]