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Inflammasomes, such as the NLRP3 inflammasome, are activated by various stimuli, including misfolded protein aggregates, oxidative stress, and mitochondrial dysfunction ( C/EBP is also implicated in the regulation of mitochondrial function and the expression of mitochondrial transcription factor A (TFAM)

Reverse transport pathway Another important consideration of the movement of lipids in the body is the reverse transport pathway (Figure 2.260)

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GST superfamily directly involves in cell proliferation as well as in sensitivity to xenobiotics, and a number of GST-knocked out mice have been established to understand the function of GSTs 11

Mutations in particular genes encoding these transportersincluding BSEP ( ABCB11 gene), MDR3 ( ABCB4 gene), sterolin-1 and sterolin-2 ( ABCG5/8 genes), and MRP2 ( ABCC2 gene)result in a wide spectrum of liver diseases, ranging from benign conditions such as Dubin-Johnson syndrome to more severe presentations like progressive familial intrahepatic cholestasis