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In a study on C57BL/6J mice, lifelong supplementation with spermidine led to a significant extension of lifespan, with improvements in mitochondrial function, reduced oxidative stress and enhanced autophagic activity (Reference Eisenberg, Knauer and Schauer22)

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In addition, studies in human subjects implicate GPx-1 in some cancers and cardiovascular diseases

Salivary gland tissue chip screening identifies candidate radioprotective drugs