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Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide

it strengthens meal-stop satiety, slows gastric emptying, and suppresses post-meal glucagon

Lyophilized stability: Up to 24 months at -20C in a sealed vial protected from light and moisture

According to the gradient descent method, the weights and thresholds of the functions are modified in several times in order to minimize the error function