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Curr Opin Cell Biol 17(5):559564

The first stage minimizes only the positions of solvent molecules and ions, and the second stage is an unrestrained minimization of all the atoms in the simulation cell

Central nervous system (CNS) development Although the action mechanisms of IGF-I in neurons have not been fully elucidated, it has been shown that IGF-I stimulates the autophosphorylation of IGF-IR[53] in a different manner to insulin[54]