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Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults

This represents an alternative strategy for metabolic applications where GH's fat-mobilizing properties are desired without the full GH/IGF-1 axis activation that GH secretagogues produce

Increased levels of these metabolites are associated with increased expression of VCAM-1, and increased leukocyte adherence to vascular endothelium in mice, suggesting that an inflammation-dependent mechanism may underly the association of these metabolites with the development of major CV adverse events (Ferrell et al, 2024)

A compromised compound mid-study can mean restarting experiments, losing funding cycles, or submitting incomplete data