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Liver dysfunction in idiopathic pulmonary arterial hypertension: prevalence, characteristics and prognostic significance, a retrospective cohort study in China

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This has begun to influence international guidelines on the selection of patients for implantable cardioverter defibrillators (ICDs) that recommend lower thresholds for such devices in patients with LMNA, FLNC, PLN or RBM20 variants and other high-risk features beyond LVEF (Zeppenfeld et al., Reference Zeppenfeld, Tfelt-Hansen, de Riva, Winkel, Behr, Blom, Charron, Corrado, Dagres, de Chillou, Eckardt, Friede, Haugaa, Hocini, Lambiase, Marijon, Merino, Peichl, Priori, Reichlin, Schulz-Menger, Sticherling, Tzeis, Verstrael, Volterrani and Group2022)

HPV infection has been shown to induce the expression of these checkpoint proteins, impairing the ability of T cells to mount an effective anti-tumor response