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Alternatively, oral capsules are available but have significantly lower bioavailability

According to Corrie et al., nanoparticles can improve efficacy and minimize side effects by extending the duration of drug circulation in the body and lowering the rate of drug clearance [188]

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While agar-based nanoparticle systems are still emerging in BBB research, several universal design principles apply: These parameters are critical in adapting established ligand systems to agar-based nanoparticle platforms