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Trp31 hTrx1 fits into a pocket, formed by residues Ala29 hTrx1 , Met74 hTrx1 , Asn107 hTrxR1 , Gly110 hTrxR1 , Ser111 hTrxR1 , Trp114 hTrxR1 , and the mixed disulphide, whereas the indole is stacked with main chain atoms of residues 110 hTrxR1 and 111 hTrxR1 (Fig

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In in vivo experiments, there was a decrease in tumor volume, preservation of lean muscle tissue, and reductions in energy expenditure and fat loss [127]