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Antioxidant enzymes in liver and kidney tissues were reduced, with an elevation in caspase-3 and caspase-9

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After transient middle cerebral artery occlusion in Nrf2 gene knockout mice, the induction and activation of antioxidant enzymes are inhibited, resulting in a larger stroke area (Zhang et al., 2017)

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Autoimmune inflammation triggers aberrant astrocytic calcium signaling to impair synaptic plasticity