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Lipopolysaccharide from biofilm-forming Pseudomonas aeruginosa PAO1 induces macrophage hyperinflammatory responses

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Subsequently, the dissociated AIMP2 translocated to the nucleus and directly interacted with tumor suppressor p53, thereby inhibiting murine double minute 2 (MDM2)-mediated ubiquitination and degradation of p53

If symptoms of tiredness do not improve after 68 weeks of appropriate treatment, patients should contact their GP, as this may indicate an alternative or additional cause requiring investigation