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Some patients experience mood changes, depression, or cognitive difficulties that may be mistakenly attributed to other causes

In the Look AHEAD (Action for Health in Diabetes) study, 37 which evaluated the effects of intensive lifestyle intervention on neuropathy in 5,145 overweight patients with type 2 diabetes, patients in the intervention group had lower pain scores and better touch sensation in the toes compared with controls at 1 year

It is worth noting that in 2018, the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) published a revised European consensus on the definition and diagnosis of sarcopenia, in which experts established a diagnostic algorithm and determined sarcopenia cut-off points

In longer studies, around half of the participants lost 15% of their body weight at 68 weeks, and nearly a third lost 20%

While both medications lead to substantial weight loss, tirzepatide appears to have the edge in terms of the amount of weight lost