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Baker, P

Part A An Official J

In high glucose conditions, E2 enhances glycolysis via enhanced AKT kinase activity and suppresses TCA cycle activity, while in low extracellular glucose conditions, E2 stimulates the TCA cycle via the upregulation of PDH activity and suppresses glycolysis to satisfy the energy requirements of the tumor cell (207)

Carboxyl-terminal fragment of Alzheimers APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity

In fact, OATP1B1 has been observed in mice and human material to play a role in cholesterol homeostasis [42], which therefore may provide an additional explanation for the present results pending specific experiments that include a fluconazole condition in the investigation of the involvement of the transporter in human cholesterol disposition