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It is described in scientific literature as part of the mitochondrialderived peptide (MDP) groupsmall peptides connected to how mitochondria communicate with the rest of the cell

The evidence ranges from preclinical animal studies to human clinical trials, and the mechanisms are diverse enough that different peptides address different aspects of nerve damage

PE-22-28: TREK-1 Channel Blockade# PE-22-28 (Gly-Val-Ser-Trp-Gly-Leu-Arg) is a synthetic 7-amino acid peptide derived from spadin, itself an endogenous peptide released by proteolytic processing of sortilin (neurotensin receptor-3)

Hampel H, Hardy J, Blennow K et al (2021) The amyloid- pathway in Alzheimers disease

It is well-established that endothelial cells play important roles for controlling coronary artery contraction/relaxation [29]