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Different studies showed that higher levels of pro-inflammatory cytokines in the CSF and plasma support the interaction between the brain and the immune system with the development of neuroinflammation and degeneration of dopaminergic neurons in PD (Jiang and Dickson 2018

doi: 10.3389/fimmu.2014.00603 186 RiksenNP

GoldmanRakic, P.S., Regional and cellular fractionation of working memory

consumption of caffeine can worsen their symptoms.2 Diet Depression Poor eating habits can contribute to de- pression by failing to provide the nutrients necessary for synthesis of important neuro- Micronutrients Anxiety Nutrient Suggested daily dose Comments Tryptophan 13 g Tryptophan can increase levels of serotonin, a brain neuro- Magnesium 400600 mg transmitter that has a calming effect.3 Should be taken together with 50 mg vitamin B6 May decrease anxiety and nervous tension.4 Medications, illness, and stress can deplete magnesium stores and pro- duce agitation and irritability Psychiatric Disorders 219 transmitters.3,5 In turn, depression can then possible sensitivities and eliminate the of- aggravate nutrient deficiencies by causing fending foods (see pp

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