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Oct 12 2019;11(10)doi:10.3390/nu11102435 Bagchi D, Bagchi M, Stohs SJ, et al

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All 180 of the cavaliers in this study were Australian, making them quite insular, and only 6 of them (0.033%) were found to have the wild-type NEBL allele

This suggests a case of parallel adaptation to dietary extremes through distinct, population-specific genetic changes: the ancestral allele, combined with the insertion, helps vegetarians better metabolize their diet, while the derived allele is best suited for marine diets ( The FADS2 insertion allele in South Asians is believed to be an adaptive response to plant-based diets that provides a metabolic advantage by ensuring sufficient AA and DHA synthesis from vegetarian food sources ( FADS alleles common in Inuit reduce levels of certain unsaturated fatty acids, which was likely beneficial in their ecology, where they consumed large amounts of seal, blubber, and fish oil daily