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Studies using chondrocyte cell models have investigated whether the GH C-terminal fragment influences cartilage matrix synthesis, chondrocyte proliferation, and growth factor expression in bone and cartilage biology research contexts

However, several studies have also shown that chronic treatment with AOD-9604 had no adverse effect on insulin sensitivity of researched animals

The critical distinction with AOD-9604 is its complete lack of effect on IGF-1 levels

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