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J Pharm Sci (2005) 94:71829

reported that inhibition of GPX4 leads to lipid peroxide accumulation in H9c2 cells and triggers ferroptotic cell death [17]

Now, let's shift to more localized, musculoskeletal goals

In vivo and in vitro experiments clarify the hierarchical regulatory mechanisms: Butyrate directly regulates Th17/Treg homeostasis, promotes Treg differentiation through the HDAC1/FoxP3 pathway, and simultaneously inhibits Th17 activation and the expression of IL-17, IL-23, and RORt (89, 90)