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Preproglucagon neurons in the nucleus of the solitary tract are the main source of brain GLP-1, mediate stress-induced hypophagia, and limit unusually large intakes of food

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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats

To establish the castration-resistant or androgen-independent (AI) xenograft lines, parental AD tumor cells were purified, mixed with Matrigel, injected subcutaneously and serially passaged in surgically castrated male immunodeficient mice