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Furthermore, compared with mature cultures, immature cultures secrete significantly more alanine and aspartate into the medium, indicating that the transamination route is the primary mechanism by which exogenous glutamate is metabolized in these cells

At the top, thyroxine (T 4 ) converts to triiodothyronine (T 3 ) via DIO1 and DIO2, or to reverse triiodothyronine (rT 3 ) via DIO1 and DIO3

Together, our data suggest that under strong pro-pancreatic conditions during in vitro differentiation, GPX2 KO cells differentiate into two distinct lineages: endocrine-like and multilineage progenitors, including liver-like progenitors

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