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A 2012 randomized controlled trial also examined the effects of an oral supplement containing forskolin and rutin in patients with POAG, who were already receiving maximum tolerated medical therapy

Constitutively expressed COX-1 is believed to function in physiologic, or housekeeping, activities such as vascular homeostasis, maintenance of renal and gastrointestinal blood flow, renal function, intestinal mucosal proliferation, platelet function, and antithrombogenesis