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Similarly, although LC-MS/MS offers high sensitivity and specificity for markers such as F2-isoprostanes or 4-HNE, its widespread use is hampered by cost, technical complexity, and the need for highly trained personnel

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this is research-chemical evidence, not clinical proof

Conflict of interest The authors have no conflicts of interest to declare

The activity of the enzyme MTRR is so critical for regeneration of MethylCo(III)B12, that certain mutations in the gene have been found to be conditionally lethal in the womb, or are associated with much higher rates of Down Syndrome, Neural Tube Defects, increased homocysteine (Garcia-Minguillan etal, 2014