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doi: 10.1182/blood-2008-03-040253 Summary Keywords vitamin B12 deficiency, hemolysis, anemia, pancytopenia, hemolytic anemia, intramedullary hemolysis Citation Sainatham C, Dy PS, Kaushik S, Tallapalli JR, Patel V, Jindal V and Paul S (2024) Case report: Vitamin B12 deficiency-associated hemolytic anemia

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After an initial loading regimen of 1mg three times weekly for two weeks, maintenance therapy is typically 1mg every three months for life in conditions like pernicious anaemia, or every two months if neurological involvement was present

However, megadosing (taking excessive amounts of vitamin B12) may lead to some negative side effects

GLUT4 upregulation depends on stable NAD+ levels, further supporting the core mechanism of nicotinamide metabolism and NAD+ elevation