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For persistent pigmentation-driven dark circles where melanin production has been occurring over years of UV exposure or inflammation, the upstream intervention is more effective than downstream distribution inhibition alone

J Hepatol 2004

EBioMedicine 59 , 102844 (2020)

[PubMed: 173994] 716

This may lead to increased warfarin sensitivity (and lower dose requirements), although the clinical significance of this interaction is highly debated