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In principle, this hyperimmune antibody-macrophage interaction would help explain why the hybrid immunity afforded by the combination of the mRNA vaccinations and coronavirus infections may confer protection against the infection while concomitantly increasing the risk of more serious AEs

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Cells were permeabilized using digitonin (1 g per 10 6 platelets or 6 g per 10 6 PBMCs), and simultaneously, the N-pathway substrates (or CI substrates) malate and pyruvate were added at saturating concentrations (5 mM each)