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We report a single-arm, open-label, pilot clinical trial assessing the efficacy and safety of topical toll-like receptor-7 (TLR-7) agonist, imiquimod, utilized in a neoadjuvant setting in early-stage oral squamous cell carcinoma (OSCC)

Holliday EB, Kocak-Uzel E, Feng L, Thaker NG, Blanchard P, Rosenthal DI , Gunn GB, Garden AS, Frank SJ

A: It should remain clear

NNMT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to nicotinamide, influencing intracellular nicotinamide availability and interacting with NAD-associated metabolic processes

But the most dramatic impact on aging is biological