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Further, comprehensive epitope mapping of the entire human SOD1 protein sequence in hSOD1 G93A , hSOD1 G85R , hSOD1 D90A , and hSOD1 WT mice demonstrated that multiple, structurally distinct SOD1 aggregates may coexist in vivo, [193] indicating a coalescence of distinct aggregation pathways

Glutathione is built in two ATP-dependent steps (glutamate-cysteine ligase, then glutathione synthetase), used in redox and detox reactions, and later cleaved by gamma-glutamyl transpeptidase the only enzyme able to break its unusual gamma peptide bond

Essential fatty acids and dietary sources The figure shows two vertical pathways of essential fatty acid metabolism, with dietary sources of the main fatty acids listed

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[PubMed] [Google Scholar] 18.Dharmarajan TS, Kanagala MR, Murakonda P, Lebelt AS, Norkus EP