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Glossary T2D Type 2 diabetes scRNA-seq Single-cell RNA sequencing ER Endoplasmic reticulum scATAC-seq Single-cell sequencing assay for transposase-accessible chromatin NGPs Next-generation probiotics GLP-1 Glucagon-like peptide-1 GLP1R Glucagon-like peptide-1 receptor GIPR Glucose-dependent insulinotropic polypeptide receptor mRNA Messenger RNA cCREs Candidate cis-regulatory elements snRNA-seq Single nucleus RNA sequencing MODY3 Maturity-onset diabetes of the young, type 3 STZ Streptozotocin FAK Focal adhesion kinase PNM factors PDX1, NGN3 and MAFA EECs Enteroendocrine cells T1D Type 1 diabetes AAb + Autoantibody-positive NK Natural killer TFs Transcription factors DEGs Differentially expressed genes SNPs Single nucleotide polymorphisms HPAP Human Pancreas Analysis Program WGBS Whole-genome bisulfite sequencing UPR Unfolded protein response DARs Differentially accessible chromatin regions HiChIP High-throughput chromatin conformation capture with immuno precipitation SCFAs Short-chain fatty acids GPCRs G-protein-coupled receptors Treg Regulatory T cells LPS Lipopolysaccharides FMT Fecal microbiota transplantation CFU Colony-forming unit HFD High-fat diet FBG Fasting blood glucose DPP-4 Dipeptidyl peptidase-4 ESCs Embryonic stem cells iPSCs Induced pluripotent stem cells References 1 AldousN.MoinA

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To obtain pgfp, a gfp containing fragment was released from pUCG-H [34] via Sma I and Sac I and subcloned into the corresponding Eco RV and Sac I sites of pGEM5zf+ (Promega)